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Health Guideline
Guidance for Diabetes Melitus
Diabetes mellitus is a disease caused by the body's blood sugar levels exceeding normal limits. There are three types of diabetes mellitus, namely:
• Type 1 diabetes mellitus is caused by damage to pancreatic beta cells which caused the pancreas to unable to produce insulin
• Type 2 diabetes mellitus is caused by the body's cells not being able to use insulin properly resulting in blood sugar not being able to produce energy
• Gestational diabetes mellitus occurs in pregnant women who do not have a history of diabetes
The cause of diabetes mellitus can occur due to genetics and unhealthy lifestyle. Common symptoms of diabetes mellitus are:
1. Polyphagia (excessive eating)
2. Polyuria (excessive urination)
3. Polydipsia (excessive thirst)
Insulin Resistance
Insulin is a hormone produced by the pancreas that functions to convert glucose (blood sugar) into glycogen. Insulin resistance is a condition when the body does not respond to the hormone insulin properly, resulting in high blood sugar levels. Insulin resistance in type 2 diabetes mellitus can be a risk factor for cancer. When blood sugar levels are still high, the body will give a signal to the pancreas to continue to release insulin.
Pancreatic cells will release the hormone insulin when blood sugar levels rise, for example after eating. The insulin hormone will then bind to the insulin receptor on the outer surface of the cell. The release of insulin is followed by the release of IGF-1 (Insulin-like Growth Factor-1) which can trigger the growth of cancer cells. Therefore, therapy is needed to regulate IGF-1 and prevent cancer.
Chronic inflammation can also occur in patients with diabetes mellitus which causes an increase in free radicals in the form of ROS (Reactive Oxygen Species) and RNS (Reactive Nitrogen Species). The high level of free radicals in the body causes antioxidants unable to compensate, resulting in oxidative stress. Prolonged oxidative stress can damage cells, tissues, and organs in the body such as the pancreas. Therefore, high blood sugar level is not the only thing that need to be treated in diabetes mellitus patients, but the chronic inflammation also needs to be treated.
The common treatments given to people with diabetes mellitus are:
1. Oral antidiabetic drugs, such as sulfonylureas (glimepiride) and biguanides (metformin)
2. Anti-hyperglycemic injection, such as insulin
The mechanism of action of oral sulfonylurea antidiabetic drugs is to increase insulin secretion, while metformin is used to decrease hepatic glucose production and increase insulin sensitivity. However, these oral antidiabetic drugs can cause side effects to watch out for, namely:
• Hypoglycemia
• Lactic acidosis
• Dyspepsia
• Diarrhea
Side effects of insulin therapy are:
• Hypoglycemia
• Allergic reactions to insulin
The HbA1C value is one of the laboratory results used in diagnosing diabetes mellitus and is also used to monitor treatments in patients who have been diagnosed with diabetes mellitus.
The following table shows the types of HbA1C values results:
There are several things that can affect the HbA1C value (increase or decrease), namely:
• Renal failure, hepatic impairment, or severe anemia
• Effects of drugs (opioids and HIV drugs)
• Less common types of hemoglobin in African, Mediterranean or Southeast Asian races and people with blood disorders (sickle cell anemia or thalassemia)
• Blood loss or blood transfusion
• Early or late pregnancy
Several scientific journals that have been published show that components of BIOTEK FARMASI INDONESIA products have antidiabetic, antioxidant, anti-inflammatory, and anti-atherosclerosis effects so that they can help relieve diabetes symptoms.
DIALANCE products are indicated to help relieve the symptoms of diabetes traditionally. Scientific journals show that the composition of this product has several advantages, namely:
1) Anti-diabetic effect
2) Antioxidant effect
3) Anti-inflammatory effect
4) Anti-atherosclerosis effect
5) Immunomodulatory effect that serves to reduce the expression of inflammatory mediators
6) Regulatory effect to EGF and IGF-1 which have anti-cancer effect
Some of the advantages above provide BENEFITS for users, namely:
1) Helps normalize the body's blood sugar levels
2) Helps overcome liver cell damage due to free radicals
3) Helps overcome inflammation / inflammation
4) Helps overcome blockage of blood vessels
5) Helps overcome the release of mediators that cause inflammation / inflammation
6) Helps overcome the growth of cancer cells
The recommended dose based on HbA1c value:
DIALANCE product from BIOTEK FARMASI INDONESIA is originator product, not imitating existing ones. This product was developed based on years of research. Please click the products page for more information.
REFERENCES
[1] S. F. Oon, M. Nallappan, T. T. Tee, S. Shohaimi, N. K. Kassim, M. S. F. Sa’ariwijaya and Y. H. Cheah, "Xanthorrhizol: a review of its pharmacological activities and anticancer properties," Cancer Cell International, pp. 1, 13, 2015.
[2] H. Itokawa, Q. Shi, T. Akiyama, S. L. Morris-Natschke and K.-H. Lee, "Recent advances in the investigation of curcuminoids," Chinese Medicine, vol. 3, pp. 1, 10-11, 2008.
[3] F. I. Hassan and A. A. MFadzilah, "Anti-Diabetic Effect Of Curcuma Xanthorrhiza On Adipogenesis Of 3t3-L1 Preadipocyte," Regenerative Research, vol. 3, p. 107, 2014.
[4] A. M. Mahmoud, R. J. H. Bautista, M. A. Sandhu and O. E. Hussein, "Beneficial Effects of Citrus Flavonoids on Cardiovascular and Metabolic Health," Oxidative Medicine and Cellular Longevity, pp. 1, 11-12, 2019.
[5] G. R. Gandhi, A. B. S. Vasconcelos, D.-T. Wu, H.-B. Li, P. J. Antony, H. Li, F. Geng, R. Q. Gurgel, N. Narain and R.-Y. Gan, "Citrus Flavonoids as Promising Phytochemicals Targeting Diabetes and Related Complications: A Systematic Review of In Vitro and In Vivo Studies," Nutrients, p. 1, 2020.
[6] M. Iman, S. A. Moallem and A. Barahoyee, "Effect of Apple Cider Vinegar on Blood Glucose Level in Diabetic Mice," Pharmaceutical Sciences, vol. 20, pp. 163, 167, 2015.
[7] D. Ousaaid, H. Laaroussi, M. Bakour, A. ElGhouizi, A. Aboulghazi, B. Lyoussi and I. ElArabi, "Beneficial Effects of Apple Vinegar on Hyperglycemia and Hyperlipidemia in Hypercaloric-Fed Rats," Journal of Diabetes Research, p. 5, 2020.
[8] S. Kausar, A. Humayun, Z. Ahmed, M. A. Abbas and A. Tahir, "Effect of Apple Cider Vinegar on Glycemic Control, Hyperlipidemia and Control on Body Weight in Type 2 Diabetes Patients," International Journal of Medical Research & Health Sciences,, vol. 8, no. 5, p. 70, 2019.
[9] P. Zenga, J. Lib, Y. Chenc and L. Zhanga, "The structures and biological functions of polysaccharides from traditional Chinese herbs," Progress in Molecular Biology and Translational Science, vol. 163, p. 437, 2019.
[10] X. Niu, J. Zhang, C. Ling, M. Bai, Y. Peng, S. Sun, Y. Li and Z. Zhang, "Polysaccharide From Angelica Sinensis Protects H9c2 Cells Against Oxidative Injury and Endoplasmic Reticulum Stress By Activating The ATF6 Pathway," Journal of International Medical Research, vol. 46, no. 5, pp. 1717-1718, 2018.
[11] Yanqiu Xia Liji Jin, Bin Zhang a, Hongyu Xue, Qiujuan Li, Yongping Xu, "The
Potentiation Of Curcumin On Insulin-Like Growth Factor-1 Action In MCF-7 Human Breast Carcinoma Cells," Life Sciences vol 80, 2161–2169, 2007.
• Type 1 diabetes mellitus is caused by damage to pancreatic beta cells which caused the pancreas to unable to produce insulin
• Type 2 diabetes mellitus is caused by the body's cells not being able to use insulin properly resulting in blood sugar not being able to produce energy
• Gestational diabetes mellitus occurs in pregnant women who do not have a history of diabetes
The cause of diabetes mellitus can occur due to genetics and unhealthy lifestyle. Common symptoms of diabetes mellitus are:
1. Polyphagia (excessive eating)
2. Polyuria (excessive urination)
3. Polydipsia (excessive thirst)
Insulin Resistance
Insulin is a hormone produced by the pancreas that functions to convert glucose (blood sugar) into glycogen. Insulin resistance is a condition when the body does not respond to the hormone insulin properly, resulting in high blood sugar levels. Insulin resistance in type 2 diabetes mellitus can be a risk factor for cancer. When blood sugar levels are still high, the body will give a signal to the pancreas to continue to release insulin.
Pancreatic cells will release the hormone insulin when blood sugar levels rise, for example after eating. The insulin hormone will then bind to the insulin receptor on the outer surface of the cell. The release of insulin is followed by the release of IGF-1 (Insulin-like Growth Factor-1) which can trigger the growth of cancer cells. Therefore, therapy is needed to regulate IGF-1 and prevent cancer.
Chronic inflammation can also occur in patients with diabetes mellitus which causes an increase in free radicals in the form of ROS (Reactive Oxygen Species) and RNS (Reactive Nitrogen Species). The high level of free radicals in the body causes antioxidants unable to compensate, resulting in oxidative stress. Prolonged oxidative stress can damage cells, tissues, and organs in the body such as the pancreas. Therefore, high blood sugar level is not the only thing that need to be treated in diabetes mellitus patients, but the chronic inflammation also needs to be treated.
The common treatments given to people with diabetes mellitus are:
1. Oral antidiabetic drugs, such as sulfonylureas (glimepiride) and biguanides (metformin)
2. Anti-hyperglycemic injection, such as insulin
The mechanism of action of oral sulfonylurea antidiabetic drugs is to increase insulin secretion, while metformin is used to decrease hepatic glucose production and increase insulin sensitivity. However, these oral antidiabetic drugs can cause side effects to watch out for, namely:
• Hypoglycemia
• Lactic acidosis
• Dyspepsia
• Diarrhea
Side effects of insulin therapy are:
• Hypoglycemia
• Allergic reactions to insulin
The HbA1C value is one of the laboratory results used in diagnosing diabetes mellitus and is also used to monitor treatments in patients who have been diagnosed with diabetes mellitus.
The following table shows the types of HbA1C values results:
There are several things that can affect the HbA1C value (increase or decrease), namely:
• Renal failure, hepatic impairment, or severe anemia
• Effects of drugs (opioids and HIV drugs)
• Less common types of hemoglobin in African, Mediterranean or Southeast Asian races and people with blood disorders (sickle cell anemia or thalassemia)
• Blood loss or blood transfusion
• Early or late pregnancy
Several scientific journals that have been published show that components of BIOTEK FARMASI INDONESIA products have antidiabetic, antioxidant, anti-inflammatory, and anti-atherosclerosis effects so that they can help relieve diabetes symptoms.
DIALANCE products are indicated to help relieve the symptoms of diabetes traditionally. Scientific journals show that the composition of this product has several advantages, namely:
1) Anti-diabetic effect
2) Antioxidant effect
3) Anti-inflammatory effect
4) Anti-atherosclerosis effect
5) Immunomodulatory effect that serves to reduce the expression of inflammatory mediators
6) Regulatory effect to EGF and IGF-1 which have anti-cancer effect
Some of the advantages above provide BENEFITS for users, namely:
1) Helps normalize the body's blood sugar levels
2) Helps overcome liver cell damage due to free radicals
3) Helps overcome inflammation / inflammation
4) Helps overcome blockage of blood vessels
5) Helps overcome the release of mediators that cause inflammation / inflammation
6) Helps overcome the growth of cancer cells
The recommended dose based on HbA1c value:
DIALANCE product from BIOTEK FARMASI INDONESIA is originator product, not imitating existing ones. This product was developed based on years of research. Please click the products page for more information.
REFERENCES
[1] S. F. Oon, M. Nallappan, T. T. Tee, S. Shohaimi, N. K. Kassim, M. S. F. Sa’ariwijaya and Y. H. Cheah, "Xanthorrhizol: a review of its pharmacological activities and anticancer properties," Cancer Cell International, pp. 1, 13, 2015.
[2] H. Itokawa, Q. Shi, T. Akiyama, S. L. Morris-Natschke and K.-H. Lee, "Recent advances in the investigation of curcuminoids," Chinese Medicine, vol. 3, pp. 1, 10-11, 2008.
[3] F. I. Hassan and A. A. MFadzilah, "Anti-Diabetic Effect Of Curcuma Xanthorrhiza On Adipogenesis Of 3t3-L1 Preadipocyte," Regenerative Research, vol. 3, p. 107, 2014.
[4] A. M. Mahmoud, R. J. H. Bautista, M. A. Sandhu and O. E. Hussein, "Beneficial Effects of Citrus Flavonoids on Cardiovascular and Metabolic Health," Oxidative Medicine and Cellular Longevity, pp. 1, 11-12, 2019.
[5] G. R. Gandhi, A. B. S. Vasconcelos, D.-T. Wu, H.-B. Li, P. J. Antony, H. Li, F. Geng, R. Q. Gurgel, N. Narain and R.-Y. Gan, "Citrus Flavonoids as Promising Phytochemicals Targeting Diabetes and Related Complications: A Systematic Review of In Vitro and In Vivo Studies," Nutrients, p. 1, 2020.
[6] M. Iman, S. A. Moallem and A. Barahoyee, "Effect of Apple Cider Vinegar on Blood Glucose Level in Diabetic Mice," Pharmaceutical Sciences, vol. 20, pp. 163, 167, 2015.
[7] D. Ousaaid, H. Laaroussi, M. Bakour, A. ElGhouizi, A. Aboulghazi, B. Lyoussi and I. ElArabi, "Beneficial Effects of Apple Vinegar on Hyperglycemia and Hyperlipidemia in Hypercaloric-Fed Rats," Journal of Diabetes Research, p. 5, 2020.
[8] S. Kausar, A. Humayun, Z. Ahmed, M. A. Abbas and A. Tahir, "Effect of Apple Cider Vinegar on Glycemic Control, Hyperlipidemia and Control on Body Weight in Type 2 Diabetes Patients," International Journal of Medical Research & Health Sciences,, vol. 8, no. 5, p. 70, 2019.
[9] P. Zenga, J. Lib, Y. Chenc and L. Zhanga, "The structures and biological functions of polysaccharides from traditional Chinese herbs," Progress in Molecular Biology and Translational Science, vol. 163, p. 437, 2019.
[10] X. Niu, J. Zhang, C. Ling, M. Bai, Y. Peng, S. Sun, Y. Li and Z. Zhang, "Polysaccharide From Angelica Sinensis Protects H9c2 Cells Against Oxidative Injury and Endoplasmic Reticulum Stress By Activating The ATF6 Pathway," Journal of International Medical Research, vol. 46, no. 5, pp. 1717-1718, 2018.
[11] Yanqiu Xia Liji Jin, Bin Zhang a, Hongyu Xue, Qiujuan Li, Yongping Xu, "The
Potentiation Of Curcumin On Insulin-Like Growth Factor-1 Action In MCF-7 Human Breast Carcinoma Cells," Life Sciences vol 80, 2161–2169, 2007.
Kidney Diseasae Guidelines
Kidney’s main function is to maintain fluid balance in the human body. The human kidney consists of two pieces, each located on the right and left of the spine.
The main kidney functions are:
1. Filtration
2. Reabsorption
3. Excretion
4. Glucose metabolism and hormone formation.
Kidney disorder is a condition where there is a decrease in kidney function, causing the function of filtering and removing substances by the kidneys to be disrupted. Common symptoms of kidney disorders are decrease in urine volume, changes in urine color, pain when urinating, pain in the back of the abdomen that can radiate to the legs, and swelling in the legs.
Kidney disorders are divided into two, namely:
1. Acute kidney disorders where the decline in kidney function occurs suddenly
2. Chronic kidney disorders where the decline in kidney function occurs gradually over 3 months
One of the functions of the kidneys is to filter the remnants of metabolism in the body. If there is a decrease in kidney function under certain conditions, the kidneys cannot perform an optimal filtering. One way to diagnose patients with kidney failure can refer to the value of GFR (Glomerular Filtration Rate).
GFR (Glomerular Filtration Rate) is the average rate of the kidney's ability to filter. GFR measurement is usually calculated by eGFR (estimated Glomerulus Filtration Rate) which is based on creatinine in blood, age, and gender. According to CKDIGO (Chronic Kidney Disease Improving Global Outcomes), the following are the stages of chronic kidney failure based on GFR values:
Damage to the kidneys is caused by chronic inflammation which can be caused by various conditions like viral infection or certain diseases detected. Prolonged chronic inflammation will cause an increase in ROS (Reactive Oxygen Species) and RNS (Reactive Nitrogen Species), which are free radicals. These large amounts of free radicals cannot be neutralized by antioxidants in the body, thus triggering oxidative stress. Oxidative stress that occurs continuously will cause damage to kidney cells, including mitochondria which is a site to produce ATP (Adenosine Tri Phosphate). Lack of ATP in the kidneys triggers a decrease in kidney function, such as decreased urine volume and difficulty urinating.
Complications that can occur due to chronic kidney disease include:
• Anemia: caused by a decrease in erythropoietin produced by the kidneys, along with a decrease in the glomerular filtration rate
• Cardiovascular disease: all patients with chronic kidney disease are advised to be considered at high risk of cardiovascular disease
• Hyperkalemia: caused by the inability of the kidneys to excrete potassium from the food intake.
• Pulmonary edema: fluid overload occurs due to impaired regulation of fluid in the kidneys in patients with chronic kidney disease
Treatment for kidney disorders can be done with non-pharmacological and pharmacological therapies. Recommended non-pharmacological treatments are diet and exercise. Whereas pharmacological or drugs treatment must be customized to the cause of the occurrence of kidney disorders, such as:
• Sodium Bicarbonate to raise the pH level and reduce acidity in the kidneys.
• Angiotensin-converting enzyme (ACE) Inhibitors / Angiotensin II receptor blockers (ARBs) to lower high blood pressure.
• Diuretic drugs such as furosemide, to increase fluid from the body.
Meanwhile, for patients with end-stage chronic kidney disease, the treatment is done by dialysis (dialysis) and kidney transplant surgery.
The combined components of several products from BIOTEK FARMASI INDONESIA have antioxidant characteristics and can increase cellular energy / ATP (Adenosine Tri Phosphate) in the kidneys which can help maintain kidney function, thus helping to ease urination.
Some of the advantages above provide benefits for users, namely:
1) Helps improve kidney function
2) Helps inhibit kidney cell damage
The recommended dose of K-FIX based on GFR values is:
K-FIX is originator product, not imitating existing ones. This product was developed based on years of research. More complete information about the product can be seen in the product menu.
REFERENSI
[1] S. Zhu, R. H. Aspera-Werz, T. Chen, W. Weng, B. Braun, T. Histing and A. K. Nüssler, "Maqui Berry Extract Prevents Cigarette Smoke Induced Oxidative Stress In Human Osteoblasts In Vitro," EXCLI Journal, p. 1, 2020.
[2] C. L. C´espedes-Acu˜na, J. Xiaob, Z.-J. Weic, L. Chend, J. M. Bastiase, J. G. Avilaf, J. Alarcon-Enosa and E. W.-N. a. I. Kubo, "Antioxidant and anti-inflammatory effects of extracts from Maqui berry Aristotelia chilensis in human colon cancer cells," Journal of Berry Research, p. 275, 2018.
[3] Z. Lu, Y. Zhong, W. Liu, L. Xiang and Y. Deng, "The Efficacy and Mechanism of Chinese Herbal Medicine on Diabetic Kidney Disease," Journal of Diabetes Research, p. 8, 2019.
[4] T. S. Laasya, S. Thakur, R. Poduri and G. Joshi, "Current insights toward kidney injury: Decrypting the dual role and mechanism involved of herbal drugs in inducing kidney injury and its treatment," Current Research in Biotechnology, p. 168, 2020.
[5] L. S. Wieland, V. Piechotta, T. Feinberg, E. Ludeman, B. Hutton, S. Kanji, D. Seely and C. Garritty, "Elderberry for prevention and treatment of viral respiratory illnesses: a systematic review," BMC Complementary Medicine and Therapies, pp. 1-2, 2021.
[6] G. T. T. Ho, HelleWangensteen and H. Barsett, "Elderberry and Elderflower Extracts, Phenolic Compounds, and Metabolites and Their Effect on Complement, RAW264.7 Macrophages and Dendritic Cells," International Journal of Molecule Science, pp. 1-2, 2017.
[7] A. B. Howell, "Bioactive compounds in cranberries and their role in prevention of urinary tract infections," Molecular Nutrition & Food Research, vol. 51, p. 732, 2007.
[8] R. G. Jepson, G. W. and J. C. Craig, "Cranberries for preventing urinary tract infections," The Cochrane Collaboration, p. 2, 2014.
[9] D. G. d. Llano, M. V. Moreno-Arribas and B. Bartolomé, "Cranberry Polyphenols and Prevention against Urinary Tract Infections: Relevant Considerations," Molecules, p. 1, 2020.
[10] R. P. Feliciano, C. G. Krueger and J. D. Reed, "Methods to determine effects of cranberry proanthocyanidins on extraintestinal infections: Relevance for urinary tract health," Molecular Nutrition & Food Research, pp. 1292, 1300, 2015.
[11] H.-I. Chou, K.-S. Chen, H.-C. Wang and W.-M. Lee, "Effects of cranberry extract on prevention of urinary tract infection in dogs and on adhesion of Escherichia coli to Madin-Darby canine kidney cells," AJVR, vol. 77, pp. 421, 426, 2015.
[12] A. P. S. Caldas, O. G. L. Coelho and J. Bressan, "Cranberry antioxidant power on oxidative stress, inflammation and mitochondrial damage," International Journal Of Food Properties, vol. 21, p. 1, 2018.
The main kidney functions are:
1. Filtration
2. Reabsorption
3. Excretion
4. Glucose metabolism and hormone formation.
Kidney disorder is a condition where there is a decrease in kidney function, causing the function of filtering and removing substances by the kidneys to be disrupted. Common symptoms of kidney disorders are decrease in urine volume, changes in urine color, pain when urinating, pain in the back of the abdomen that can radiate to the legs, and swelling in the legs.
Kidney disorders are divided into two, namely:
1. Acute kidney disorders where the decline in kidney function occurs suddenly
2. Chronic kidney disorders where the decline in kidney function occurs gradually over 3 months
One of the functions of the kidneys is to filter the remnants of metabolism in the body. If there is a decrease in kidney function under certain conditions, the kidneys cannot perform an optimal filtering. One way to diagnose patients with kidney failure can refer to the value of GFR (Glomerular Filtration Rate).
GFR (Glomerular Filtration Rate) is the average rate of the kidney's ability to filter. GFR measurement is usually calculated by eGFR (estimated Glomerulus Filtration Rate) which is based on creatinine in blood, age, and gender. According to CKDIGO (Chronic Kidney Disease Improving Global Outcomes), the following are the stages of chronic kidney failure based on GFR values:
Damage to the kidneys is caused by chronic inflammation which can be caused by various conditions like viral infection or certain diseases detected. Prolonged chronic inflammation will cause an increase in ROS (Reactive Oxygen Species) and RNS (Reactive Nitrogen Species), which are free radicals. These large amounts of free radicals cannot be neutralized by antioxidants in the body, thus triggering oxidative stress. Oxidative stress that occurs continuously will cause damage to kidney cells, including mitochondria which is a site to produce ATP (Adenosine Tri Phosphate). Lack of ATP in the kidneys triggers a decrease in kidney function, such as decreased urine volume and difficulty urinating.
Complications that can occur due to chronic kidney disease include:
• Anemia: caused by a decrease in erythropoietin produced by the kidneys, along with a decrease in the glomerular filtration rate
• Cardiovascular disease: all patients with chronic kidney disease are advised to be considered at high risk of cardiovascular disease
• Hyperkalemia: caused by the inability of the kidneys to excrete potassium from the food intake.
• Pulmonary edema: fluid overload occurs due to impaired regulation of fluid in the kidneys in patients with chronic kidney disease
Treatment for kidney disorders can be done with non-pharmacological and pharmacological therapies. Recommended non-pharmacological treatments are diet and exercise. Whereas pharmacological or drugs treatment must be customized to the cause of the occurrence of kidney disorders, such as:
• Sodium Bicarbonate to raise the pH level and reduce acidity in the kidneys.
• Angiotensin-converting enzyme (ACE) Inhibitors / Angiotensin II receptor blockers (ARBs) to lower high blood pressure.
• Diuretic drugs such as furosemide, to increase fluid from the body.
Meanwhile, for patients with end-stage chronic kidney disease, the treatment is done by dialysis (dialysis) and kidney transplant surgery.
The combined components of several products from BIOTEK FARMASI INDONESIA have antioxidant characteristics and can increase cellular energy / ATP (Adenosine Tri Phosphate) in the kidneys which can help maintain kidney function, thus helping to ease urination.
Some of the advantages above provide benefits for users, namely:
1) Helps improve kidney function
2) Helps inhibit kidney cell damage
The recommended dose of K-FIX based on GFR values is:
K-FIX is originator product, not imitating existing ones. This product was developed based on years of research. More complete information about the product can be seen in the product menu.
REFERENSI
[1] S. Zhu, R. H. Aspera-Werz, T. Chen, W. Weng, B. Braun, T. Histing and A. K. Nüssler, "Maqui Berry Extract Prevents Cigarette Smoke Induced Oxidative Stress In Human Osteoblasts In Vitro," EXCLI Journal, p. 1, 2020.
[2] C. L. C´espedes-Acu˜na, J. Xiaob, Z.-J. Weic, L. Chend, J. M. Bastiase, J. G. Avilaf, J. Alarcon-Enosa and E. W.-N. a. I. Kubo, "Antioxidant and anti-inflammatory effects of extracts from Maqui berry Aristotelia chilensis in human colon cancer cells," Journal of Berry Research, p. 275, 2018.
[3] Z. Lu, Y. Zhong, W. Liu, L. Xiang and Y. Deng, "The Efficacy and Mechanism of Chinese Herbal Medicine on Diabetic Kidney Disease," Journal of Diabetes Research, p. 8, 2019.
[4] T. S. Laasya, S. Thakur, R. Poduri and G. Joshi, "Current insights toward kidney injury: Decrypting the dual role and mechanism involved of herbal drugs in inducing kidney injury and its treatment," Current Research in Biotechnology, p. 168, 2020.
[5] L. S. Wieland, V. Piechotta, T. Feinberg, E. Ludeman, B. Hutton, S. Kanji, D. Seely and C. Garritty, "Elderberry for prevention and treatment of viral respiratory illnesses: a systematic review," BMC Complementary Medicine and Therapies, pp. 1-2, 2021.
[6] G. T. T. Ho, HelleWangensteen and H. Barsett, "Elderberry and Elderflower Extracts, Phenolic Compounds, and Metabolites and Their Effect on Complement, RAW264.7 Macrophages and Dendritic Cells," International Journal of Molecule Science, pp. 1-2, 2017.
[7] A. B. Howell, "Bioactive compounds in cranberries and their role in prevention of urinary tract infections," Molecular Nutrition & Food Research, vol. 51, p. 732, 2007.
[8] R. G. Jepson, G. W. and J. C. Craig, "Cranberries for preventing urinary tract infections," The Cochrane Collaboration, p. 2, 2014.
[9] D. G. d. Llano, M. V. Moreno-Arribas and B. Bartolomé, "Cranberry Polyphenols and Prevention against Urinary Tract Infections: Relevant Considerations," Molecules, p. 1, 2020.
[10] R. P. Feliciano, C. G. Krueger and J. D. Reed, "Methods to determine effects of cranberry proanthocyanidins on extraintestinal infections: Relevance for urinary tract health," Molecular Nutrition & Food Research, pp. 1292, 1300, 2015.
[11] H.-I. Chou, K.-S. Chen, H.-C. Wang and W.-M. Lee, "Effects of cranberry extract on prevention of urinary tract infection in dogs and on adhesion of Escherichia coli to Madin-Darby canine kidney cells," AJVR, vol. 77, pp. 421, 426, 2015.
[12] A. P. S. Caldas, O. G. L. Coelho and J. Bressan, "Cranberry antioxidant power on oxidative stress, inflammation and mitochondrial damage," International Journal Of Food Properties, vol. 21, p. 1, 2018.
Guideline for Autoimmune Disorder
Autoimmune disorders are conditions when a person's immune system attacks and destroys healthy body tissues. This happens due to the immune system cannot distinguish between healthy body tissue and foreign objects that are harmful to the body. Some autoimmune diseases target one organ, such as type 1 diabetes which damages the pancreas.
Other diseases, such as Systemic Lupus Erythematosus (SLE), can affect the entire body. Systemic Lupus Erythematosus (SLE) or commonly known to the public as ‘the disease with a thousand faces’ is a complex autoimmune disease characterized by the formation of autoantibodies that attack healthy cells, tissues and organs, causing severe inflammation, coupled with other clinical symptoms.
The formation of autoantibodies is related to the release of NF-ĸB (Nuclear Factor-Kappa Beta) which is a transcription factor that plays an important role in the regulation of the immune system and inflammatory processes. Activation of NF-ĸB is a normal biological response of the body as a defense from various stimuli that harm the body. The presence of activation of NF-kB will form a balance of the immune system.
Under certain conditions, excessive activation of NF-ĸB will cause an imbalance in the immune system. This imbalance also leads to activation of inflammatory mediators, such as cytokines. Excessive cytokines like TNFα (Tumor Necrosis Factor alpha) and IL-6 (Interleukin 6) will cause severe inflammation even in healthy organs, therefore SLE can affect almost all organs such as joints, skin, brain, eyes, endocrine, lungs, kidneys, and blood vessels.
Early symptoms of this disease are very diverse and often similar to other diseases, so it is quite difficult to detect as early as possible. SLE symptoms can develop suddenly or can last a long time before they relapse.
Symptoms of SLE that often appear are:
• Fever
• Fatigue
• Unusual bleeding
• Hair loss
• Anemia
• Photosensitivity
• Joint pain
• Red rash on cheeks and nose
• Fingers turn pale or blue when cold.
The diagnosis of SLE is made based on the clinical symptoms experienced and investigations. Examination of CRP (C-Reactive Protein), ANA (Anti-Nuclear Antibody), RF Factor (Rheumatoid Factor), and ESR (Erythrocyte Sedimentation Rate) are needed to help diagnose autoimmune disorders.
This laboratory examination to help see the presence of inflammation in the body and autoantibodies that are produced in excess due to impaired immune balance.
The goal of therapy for SLE is to reduce symptoms and protect organs by reducing inflammation or autoimmune activity in the body. Treatment for SLE is based on the severity (mild, moderate, and severe).
Treatments commonly given to SLE patients are:
1. Corticosteroids, such as methylprednisolone, prednisone, dexamethasone.
2. Non-Steroid Anti-Inflammatory Drugs (NSAIDs), such as ibuprofen
3. Immunosuppressants, such as methotrexate and cyclosporine.
4. Biological agents, such as tocilizumab.
5. Antimalarials, such as hydroxychloroquine or chloroquine
Drugs for SLE therapy have various side effects, such as steroids that can cause a moon face (swelling of the face). Giving drugs that suppress the body's immune system makes SLE patients are more susceptible to viral infections, including the COVID-19 virus. Therefore, patients with SLE are required to maintain their health and have regular check-ups with the doctor.
BIOTEK FARMASI INDONESIA has REGIMUN product which is indicated to help maintain body’s immunity. Scientific journals show that the composition of this product has several benefits, namely:
1. Immune regulation, especially NF-kB (Nuclear Factor-kappa beta) and TNF (Tumor Necrosis Factor) which are inflammatory mediators that play a role in the imbalance of the immune system in producing autoantibodies that attack healthy organs.
2. Anti-inflammatory effect
Some of the advantages above provide benefits for users, namely:
1) Helps overcome organ damage due to immune system imbalance
2) Helps overcome inflammation / inflammation
The recommended dose based on ANA (Anti-Nuclear Antibodies) values:
REGIMUN from BIOTEK FARMASI INDONESIA is originator product, not imitating existing ones. This product was developed based on years of research.
Please click the page for more information.
REFERENCES
[1] S. Zhu, R. H. Aspera-Werz, T. Chen, W. Weng, B. Braun, T. Histing and A. K. Nüssler, "Maqui Berry Extract Prevents Cigarette Smoke Induced Oxidative Stress In Human Osteoblasts In Vitro," EXCLI Journal, vol. 20, pp. 281, 291, 2021.
[2] C. L. C´espedes-Acu˜na, J. Xiao, Z.-J. Wei, L. Chend, J. M. Bastias, J. G. Avila, J. Alarcon-Enos, E. Werner-Navarrete and I. Kubog, "Antioxidant And Anti-Inflammatory Effects Of Extracts From Maqui Berry Aristotelia Chilensis In Human Colon Cancer Cells," Journal of Berry Research, vol. 8, p. 275, 2018.
[3] L. S. Wieland, V. Piechotta, T. Feinberg, E. Ludeman, B. Hutton, S. Kanji, D. Seely and C. Garritty, "Elderberry For Prevention And Treatment Of Viral Respiratory Illnesses: A Systematic Review," BMC Complementary Medicine and Therapies, vol. 21, pp. 1-2, 2021.
[4] G. T. T. Ho, HelleWangensteen and H. Barsett, "Elderberry and Elderflower Extracts, Phenolic Compounds, and Metabolites and Their Effect on Complement, RAW264.7 Macrophages and Dendritic Cells," International Journal of Molecular Sciences, vol. 18, pp. 1-2, 2017.
[5] L. Ma, Z. Sun, Y. Zeng, M. Luo and J. Yang, "Molecular Mechanism and Health Role of Functional Ingredients in Blueberry for Chronic Disease in Human Beings," International Journal of Molecular Science, vol. 19, p. 12, 2018.
[6] S. Roth, M. R. Spalinger, I. Müller, S. Lang, G. Rogler and M. Scharl, "Bilberry-Derived Anthocyanins Prevent IFN--Induced Pro-Inflammatory Signalling and Cytokine Secretion In Human THP-1 Monocytic," Digestion, pp. 179-180, 2014.
Other diseases, such as Systemic Lupus Erythematosus (SLE), can affect the entire body. Systemic Lupus Erythematosus (SLE) or commonly known to the public as ‘the disease with a thousand faces’ is a complex autoimmune disease characterized by the formation of autoantibodies that attack healthy cells, tissues and organs, causing severe inflammation, coupled with other clinical symptoms.
The formation of autoantibodies is related to the release of NF-ĸB (Nuclear Factor-Kappa Beta) which is a transcription factor that plays an important role in the regulation of the immune system and inflammatory processes. Activation of NF-ĸB is a normal biological response of the body as a defense from various stimuli that harm the body. The presence of activation of NF-kB will form a balance of the immune system.
Under certain conditions, excessive activation of NF-ĸB will cause an imbalance in the immune system. This imbalance also leads to activation of inflammatory mediators, such as cytokines. Excessive cytokines like TNFα (Tumor Necrosis Factor alpha) and IL-6 (Interleukin 6) will cause severe inflammation even in healthy organs, therefore SLE can affect almost all organs such as joints, skin, brain, eyes, endocrine, lungs, kidneys, and blood vessels.
Early symptoms of this disease are very diverse and often similar to other diseases, so it is quite difficult to detect as early as possible. SLE symptoms can develop suddenly or can last a long time before they relapse.
Symptoms of SLE that often appear are:
• Fever
• Fatigue
• Unusual bleeding
• Hair loss
• Anemia
• Photosensitivity
• Joint pain
• Red rash on cheeks and nose
• Fingers turn pale or blue when cold.
The diagnosis of SLE is made based on the clinical symptoms experienced and investigations. Examination of CRP (C-Reactive Protein), ANA (Anti-Nuclear Antibody), RF Factor (Rheumatoid Factor), and ESR (Erythrocyte Sedimentation Rate) are needed to help diagnose autoimmune disorders.
This laboratory examination to help see the presence of inflammation in the body and autoantibodies that are produced in excess due to impaired immune balance.
The goal of therapy for SLE is to reduce symptoms and protect organs by reducing inflammation or autoimmune activity in the body. Treatment for SLE is based on the severity (mild, moderate, and severe).
Treatments commonly given to SLE patients are:
1. Corticosteroids, such as methylprednisolone, prednisone, dexamethasone.
2. Non-Steroid Anti-Inflammatory Drugs (NSAIDs), such as ibuprofen
3. Immunosuppressants, such as methotrexate and cyclosporine.
4. Biological agents, such as tocilizumab.
5. Antimalarials, such as hydroxychloroquine or chloroquine
Drugs for SLE therapy have various side effects, such as steroids that can cause a moon face (swelling of the face). Giving drugs that suppress the body's immune system makes SLE patients are more susceptible to viral infections, including the COVID-19 virus. Therefore, patients with SLE are required to maintain their health and have regular check-ups with the doctor.
BIOTEK FARMASI INDONESIA has REGIMUN product which is indicated to help maintain body’s immunity. Scientific journals show that the composition of this product has several benefits, namely:
1. Immune regulation, especially NF-kB (Nuclear Factor-kappa beta) and TNF (Tumor Necrosis Factor) which are inflammatory mediators that play a role in the imbalance of the immune system in producing autoantibodies that attack healthy organs.
2. Anti-inflammatory effect
Some of the advantages above provide benefits for users, namely:
1) Helps overcome organ damage due to immune system imbalance
2) Helps overcome inflammation / inflammation
The recommended dose based on ANA (Anti-Nuclear Antibodies) values:
REGIMUN from BIOTEK FARMASI INDONESIA is originator product, not imitating existing ones. This product was developed based on years of research.
Please click the page for more information.
REFERENCES
[1] S. Zhu, R. H. Aspera-Werz, T. Chen, W. Weng, B. Braun, T. Histing and A. K. Nüssler, "Maqui Berry Extract Prevents Cigarette Smoke Induced Oxidative Stress In Human Osteoblasts In Vitro," EXCLI Journal, vol. 20, pp. 281, 291, 2021.
[2] C. L. C´espedes-Acu˜na, J. Xiao, Z.-J. Wei, L. Chend, J. M. Bastias, J. G. Avila, J. Alarcon-Enos, E. Werner-Navarrete and I. Kubog, "Antioxidant And Anti-Inflammatory Effects Of Extracts From Maqui Berry Aristotelia Chilensis In Human Colon Cancer Cells," Journal of Berry Research, vol. 8, p. 275, 2018.
[3] L. S. Wieland, V. Piechotta, T. Feinberg, E. Ludeman, B. Hutton, S. Kanji, D. Seely and C. Garritty, "Elderberry For Prevention And Treatment Of Viral Respiratory Illnesses: A Systematic Review," BMC Complementary Medicine and Therapies, vol. 21, pp. 1-2, 2021.
[4] G. T. T. Ho, HelleWangensteen and H. Barsett, "Elderberry and Elderflower Extracts, Phenolic Compounds, and Metabolites and Their Effect on Complement, RAW264.7 Macrophages and Dendritic Cells," International Journal of Molecular Sciences, vol. 18, pp. 1-2, 2017.
[5] L. Ma, Z. Sun, Y. Zeng, M. Luo and J. Yang, "Molecular Mechanism and Health Role of Functional Ingredients in Blueberry for Chronic Disease in Human Beings," International Journal of Molecular Science, vol. 19, p. 12, 2018.
[6] S. Roth, M. R. Spalinger, I. Müller, S. Lang, G. Rogler and M. Scharl, "Bilberry-Derived Anthocyanins Prevent IFN--Induced Pro-Inflammatory Signalling and Cytokine Secretion In Human THP-1 Monocytic," Digestion, pp. 179-180, 2014.
Guideline for COVID-19
The SARS-Cov-2 virus (Severe Acute Respiratory Syndrome Coronavirus 2) is a very small genetic material that has three main components, namely Ribonucleic acid (RNA), Protein, and Lipid. At the core of the coronavirus, there is a carrier of genetic information called RNA. The single strand of RNA acts as a molecular message that allows the production of proteins needed for other elements of the virus. Nucleoproteins are proteins bound to RNA sequences that help give the virus a structure and allow them to replicate. Coronavirus’ spike proteins act like a magnet allowing the virus to attach to host cells and open them up for infection. Like all viruses, Coronavirus cannot develop and reproduce outside of a host cell.
Coronavirus will enter the body through the nose and mouth. The Coronavirus that attacks the respiratory tract is transmitted through droplets when someone is either talking, sneezing, or coughing. The most common symptoms of the Coronavirus are fever, dry cough, fatigue, diarrhea, skin rash, loss of sense of taste and smell, and difficulty breathing.
The occurrence of COVID-19, which began with the entry of the Coronavirus into body cells, consisted of several stages involving the ACE2 and TMPRSS2 enzymes. Coronavirus that enters the body binds to the Angiotensin Converting Enzyme-2 (ACE2) receptor and will be activated by TMPRSS2 (Transmembrane Protease Serine 2). Coronavirus that is bound to the ACE2 receptor will enter the cell, carry out RNA replication thus the number of the virus is increasing.
Coronavirus that enters the body will cause the body's immune response and cause inflammation. Inflammation can trigger the formation of free radicals in the form of Reactive Oxygen Species (ROS) and Reactive Nitrogen Species (RNS). There are actually antioxidants in the body to neutralize free radicals. However, under certain conditions, antioxidants in the body are unable to outnumber free radicals, resulting in oxidative stress. Oxidative stress can cause cell damage including mitochondria.
Mitochondria are part of the cell that functions as a producer of energy in the form of ATP (Adenosine Triphosphate). This is what causes patients infected with the coronavirus to feel weak. Inflammation that occurs due to coronavirus infection can also become very severe due to the occurrence of cytokine storms which if continued, it can cause damage to body organs causing symptoms such as shortness of breath, loss of smell, blood clots, and can continue to cause further damage to multi-organs such as lungs, gastrointestinal tract, brain, heart, liver, kidneys, eyes.
Treatments commonly given to COVID-19 patients :
1. Symptomatic treatment or medical therapy of a disease that only affects its symptoms. For example, if you have a fever, antipyretic drugs (fever lowering) such as paracetamol are given
2. Antivirals, such as remdesivir and/or favipiravir to inhibit viral replication (multiplication in human cells). Antivirals are not able to prevent the virus from entering cells.
3. Antioxidants, such as vitamins C, D, E, and Zinc to prevent cell damage
4. Anti-inflammatory, immunosuppressant such as steroids to treat inflammation and suppress cytokine storms
5. Antibiotics, such as azithromycin to treat secondary bacterial infections
The side effects of taking anti-inflammatory long-term, like steroids, can suppress the HPA axis (Hypothalamus Pituitary Adrenal) causing unwanted side effects including suppressing the body's immune system.
The use of antioxidants in COVID-19 patients is beneficial in overcoming oxidative stress. It is important to know that antioxidants have different potentials from one another. In this case, the ORAC (Oxygen Radical Absorbance Capacity) benchmark is used to determine how much antioxidants can be absorbed by the body. The higher the ORAC value, the better the potential of an antioxidant. One fruit that has a high ORAC value is Maqui berry (Aristotelia chilensis) with an ORAC value of 10,000-25,000 μmol TE/100 g fw. 1 tablet of vitamin C is worth a maximum of 100 ORAC value, while 1 capsule of VIRADEF is worth 10,000 ORAC. Antioxidants such as vitamin C should not be used excessively, since they have the potential to cause oxalate crystals in the form of kidney stones.
Keep in mind that existing antivirals on the market cannot inhibit viruses from entering cells, instead they work to prevent viral replication after the virus has entered the cells. Meanwhile, VIRADEF products from BIOTEK FARMASI INDONESIA can help inhibit viruses from entering the body.
VIRADEF products are indicated to help maintain body. Scientific journals show that the composition of this product has several FEATURES or characteristics, namely:
1) Inhibits TMPRSS2 which activates the coronavirus entering the body
2) Has antioxidants that can reduce oxidative stress
3) Has anti-inflammatory effect
4) Increase cellular energy/ATP (Adenosine Triphosphate) and increase muscle strength
Some of the FEATURES above provide BENEFITS for users, namely:
1) Helps prevent viral infections from entering the body
2) Helps inhibit cell, tissue, and organ damage
3) Helps overcome inflammation/inflammation caused by cytokine storms
4) Helps increase energy lost due to viral infections
The recommended dose of VIRADEF :
VIRADEF from BIOTEK FARMASI INDONESIA is originator product, not imitating existing ones. This product was developed based on years of research.
Please click the products page for more information.
REFERENCES :
[1] A. Tsoupras, D. Moran, T. Byrne, J. Ryan, L. Barrett, C. Traas and I. Zabetakis, "Anti-Inflammatory and Anti-Platelet Properties of Lipid Bioactives from Apple Cider By-Products," MPDI, vol. 26, pp. 1-2, 2021.
[2] M. Jahantigh, H. Kalantari, S. A. Davari and D. Saadati, "Effects of dietary vinegar on performance, immune response and small intestine histomorphology in 1- to 28-day broiler chickens," Veterinary Medicine and Science, vol. 7, pp. 766-767, 771, 2020.
[3] H. A. Motlagh, A. Javadmanesh and O. Safari, "Improvement of non-specific immunity, growth, and activity of digestive enzymes in Carassius auratus as a result of apple cider vinegar administration to diet," Fish Physiol Biochem, p. 1, 2020.
[4] R. W. J. K. Dhanjal, V. Kumar, S. C. Kaul and D. Sundar, "Why Ashwagandha for Prevention and Treatment of COVID-19?," Applied Microbiology, vol. 3, no. 3, pp. 1-2, 2020.
[5] P. Shree, P. Mishra, C. Selvara, S. K. Singh, R. Chaube, N. Garg and Y. B. Tripathi, "Targeting COVID-19 (SARS-CoV-2) main protease through active phytochemicals of ayurvedic medicinal plants – Withania somnifera (Ashwagandha), Tinospora cordifolia (Giloy) and Ocimum sanctum (Tulsi) – a molecular docking study," JOURNAL OF BIOMOLECULAR STRUCTURE AND DYNAMICS, p. 3, 2020.
[6] M. K. Tripathia, P. Singh, S. Sharma, T. P. Singh, A. S. Ethayathulla and P. Kaur, "Identification of bioactive molecule from Withania somnifera (Ashwagandha) as SARS-CoV-2 main protease inhibitor," JOURNAL OF BIOMOLECULAR STRUCTURE AND DYNAMICS, pp. 1-2, 2020.
[7] S. Wankhede, D. Langade, K. Joshi, S. R. Sinha and S. Bhattacharyya, "Examining the effect of Withania somnifera supplementation on muscle strength and recovery: a randomized controlled trial," Journal of the International Society of Sports Nutrition, pp. 1-11, 2015.
[8] S. Vidyashankara, O. Thiyagarajana, R. S. Varmaa, L. S. Kumarb, U. V. Babub and P. S. Patkic, "Ashwagandha (Withania somnifera) supercritical CO2 extract derived withanolides mitigates Bisphenol A induced mitochondrial toxicity in HepG2 cells," Toxicology Reports, pp. 1004-1005, 2014.
[9] M. Dhawan, M. Parmar, K. Sharun, R. Tiwari, M. Bilal and K. Dhama, "Medicinal and therapeutic potential of withanolides from Withania somnifera against COVID-19," Journal of Applied Pharmaceutical Science, vol. 11, no. 4, pp. 006-011, 2021.
[10] A. B. Kunnumakkara, V. Rana, D. Parama, K. Banik, S. Girisa, H. Sahu, K. K. Thakur, U. Dutta, P. Garodia3, S. C. Gupta and B. B. Aggarwal, "COVID-19, Cytokines, Inflammation, and Spices: How are They Related?," Life Sciences, 2020.
[11] R. Grzanna, L. Lindmark and a. C. G. Frondoza, "Ginger—An Herbal Medicinal Product with Broad Anti-Inflammatory Actions," JOURNAL OF MEDICINAL FOOD, vol. 8, no. 2, p. 130, 2005.
Coronavirus will enter the body through the nose and mouth. The Coronavirus that attacks the respiratory tract is transmitted through droplets when someone is either talking, sneezing, or coughing. The most common symptoms of the Coronavirus are fever, dry cough, fatigue, diarrhea, skin rash, loss of sense of taste and smell, and difficulty breathing.
The occurrence of COVID-19, which began with the entry of the Coronavirus into body cells, consisted of several stages involving the ACE2 and TMPRSS2 enzymes. Coronavirus that enters the body binds to the Angiotensin Converting Enzyme-2 (ACE2) receptor and will be activated by TMPRSS2 (Transmembrane Protease Serine 2). Coronavirus that is bound to the ACE2 receptor will enter the cell, carry out RNA replication thus the number of the virus is increasing.
Coronavirus that enters the body will cause the body's immune response and cause inflammation. Inflammation can trigger the formation of free radicals in the form of Reactive Oxygen Species (ROS) and Reactive Nitrogen Species (RNS). There are actually antioxidants in the body to neutralize free radicals. However, under certain conditions, antioxidants in the body are unable to outnumber free radicals, resulting in oxidative stress. Oxidative stress can cause cell damage including mitochondria.
Mitochondria are part of the cell that functions as a producer of energy in the form of ATP (Adenosine Triphosphate). This is what causes patients infected with the coronavirus to feel weak. Inflammation that occurs due to coronavirus infection can also become very severe due to the occurrence of cytokine storms which if continued, it can cause damage to body organs causing symptoms such as shortness of breath, loss of smell, blood clots, and can continue to cause further damage to multi-organs such as lungs, gastrointestinal tract, brain, heart, liver, kidneys, eyes.
Treatments commonly given to COVID-19 patients :
1. Symptomatic treatment or medical therapy of a disease that only affects its symptoms. For example, if you have a fever, antipyretic drugs (fever lowering) such as paracetamol are given
2. Antivirals, such as remdesivir and/or favipiravir to inhibit viral replication (multiplication in human cells). Antivirals are not able to prevent the virus from entering cells.
3. Antioxidants, such as vitamins C, D, E, and Zinc to prevent cell damage
4. Anti-inflammatory, immunosuppressant such as steroids to treat inflammation and suppress cytokine storms
5. Antibiotics, such as azithromycin to treat secondary bacterial infections
The side effects of taking anti-inflammatory long-term, like steroids, can suppress the HPA axis (Hypothalamus Pituitary Adrenal) causing unwanted side effects including suppressing the body's immune system.
The use of antioxidants in COVID-19 patients is beneficial in overcoming oxidative stress. It is important to know that antioxidants have different potentials from one another. In this case, the ORAC (Oxygen Radical Absorbance Capacity) benchmark is used to determine how much antioxidants can be absorbed by the body. The higher the ORAC value, the better the potential of an antioxidant. One fruit that has a high ORAC value is Maqui berry (Aristotelia chilensis) with an ORAC value of 10,000-25,000 μmol TE/100 g fw. 1 tablet of vitamin C is worth a maximum of 100 ORAC value, while 1 capsule of VIRADEF is worth 10,000 ORAC. Antioxidants such as vitamin C should not be used excessively, since they have the potential to cause oxalate crystals in the form of kidney stones.
Keep in mind that existing antivirals on the market cannot inhibit viruses from entering cells, instead they work to prevent viral replication after the virus has entered the cells. Meanwhile, VIRADEF products from BIOTEK FARMASI INDONESIA can help inhibit viruses from entering the body.
VIRADEF products are indicated to help maintain body. Scientific journals show that the composition of this product has several FEATURES or characteristics, namely:
1) Inhibits TMPRSS2 which activates the coronavirus entering the body
2) Has antioxidants that can reduce oxidative stress
3) Has anti-inflammatory effect
4) Increase cellular energy/ATP (Adenosine Triphosphate) and increase muscle strength
Some of the FEATURES above provide BENEFITS for users, namely:
1) Helps prevent viral infections from entering the body
2) Helps inhibit cell, tissue, and organ damage
3) Helps overcome inflammation/inflammation caused by cytokine storms
4) Helps increase energy lost due to viral infections
The recommended dose of VIRADEF :
VIRADEF from BIOTEK FARMASI INDONESIA is originator product, not imitating existing ones. This product was developed based on years of research.
Please click the products page for more information.
REFERENCES :
[1] A. Tsoupras, D. Moran, T. Byrne, J. Ryan, L. Barrett, C. Traas and I. Zabetakis, "Anti-Inflammatory and Anti-Platelet Properties of Lipid Bioactives from Apple Cider By-Products," MPDI, vol. 26, pp. 1-2, 2021.
[2] M. Jahantigh, H. Kalantari, S. A. Davari and D. Saadati, "Effects of dietary vinegar on performance, immune response and small intestine histomorphology in 1- to 28-day broiler chickens," Veterinary Medicine and Science, vol. 7, pp. 766-767, 771, 2020.
[3] H. A. Motlagh, A. Javadmanesh and O. Safari, "Improvement of non-specific immunity, growth, and activity of digestive enzymes in Carassius auratus as a result of apple cider vinegar administration to diet," Fish Physiol Biochem, p. 1, 2020.
[4] R. W. J. K. Dhanjal, V. Kumar, S. C. Kaul and D. Sundar, "Why Ashwagandha for Prevention and Treatment of COVID-19?," Applied Microbiology, vol. 3, no. 3, pp. 1-2, 2020.
[5] P. Shree, P. Mishra, C. Selvara, S. K. Singh, R. Chaube, N. Garg and Y. B. Tripathi, "Targeting COVID-19 (SARS-CoV-2) main protease through active phytochemicals of ayurvedic medicinal plants – Withania somnifera (Ashwagandha), Tinospora cordifolia (Giloy) and Ocimum sanctum (Tulsi) – a molecular docking study," JOURNAL OF BIOMOLECULAR STRUCTURE AND DYNAMICS, p. 3, 2020.
[6] M. K. Tripathia, P. Singh, S. Sharma, T. P. Singh, A. S. Ethayathulla and P. Kaur, "Identification of bioactive molecule from Withania somnifera (Ashwagandha) as SARS-CoV-2 main protease inhibitor," JOURNAL OF BIOMOLECULAR STRUCTURE AND DYNAMICS, pp. 1-2, 2020.
[7] S. Wankhede, D. Langade, K. Joshi, S. R. Sinha and S. Bhattacharyya, "Examining the effect of Withania somnifera supplementation on muscle strength and recovery: a randomized controlled trial," Journal of the International Society of Sports Nutrition, pp. 1-11, 2015.
[8] S. Vidyashankara, O. Thiyagarajana, R. S. Varmaa, L. S. Kumarb, U. V. Babub and P. S. Patkic, "Ashwagandha (Withania somnifera) supercritical CO2 extract derived withanolides mitigates Bisphenol A induced mitochondrial toxicity in HepG2 cells," Toxicology Reports, pp. 1004-1005, 2014.
[9] M. Dhawan, M. Parmar, K. Sharun, R. Tiwari, M. Bilal and K. Dhama, "Medicinal and therapeutic potential of withanolides from Withania somnifera against COVID-19," Journal of Applied Pharmaceutical Science, vol. 11, no. 4, pp. 006-011, 2021.
[10] A. B. Kunnumakkara, V. Rana, D. Parama, K. Banik, S. Girisa, H. Sahu, K. K. Thakur, U. Dutta, P. Garodia3, S. C. Gupta and B. B. Aggarwal, "COVID-19, Cytokines, Inflammation, and Spices: How are They Related?," Life Sciences, 2020.
[11] R. Grzanna, L. Lindmark and a. C. G. Frondoza, "Ginger—An Herbal Medicinal Product with Broad Anti-Inflammatory Actions," JOURNAL OF MEDICINAL FOOD, vol. 8, no. 2, p. 130, 2005.
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