Guideline for Autoimmune Disorder
Guideline for Autoimmune Disorder
Guideline for Autoimmune Disorder
Autoimmune disorders are conditions when a person's immune system attacks and destroys healthy body tissues. This happens due to the immune system cannot distinguish between healthy body tissue and foreign objects that are harmful to the body. Some autoimmune diseases target one organ, such as type 1 diabetes which damages the pancreas.
Other diseases, such as Systemic Lupus Erythematosus (SLE), can affect the entire body. Systemic Lupus Erythematosus (SLE) or commonly known to the public as ‘the disease with a thousand faces’ is a complex autoimmune disease characterized by the formation of autoantibodies that attack healthy cells, tissues and organs, causing severe inflammation, coupled with other clinical symptoms.
The formation of autoantibodies is related to the release of NF-ĸB (Nuclear Factor-Kappa Beta) which is a transcription factor that plays an important role in the regulation of the immune system and inflammatory processes. Activation of NF-ĸB is a normal biological response of the body as a defense from various stimuli that harm the body. The presence of activation of NF-kB will form a balance of the immune system.
Under certain conditions, excessive activation of NF-ĸB will cause an imbalance in the immune system. This imbalance also leads to activation of inflammatory mediators, such as cytokines. Excessive cytokines like TNFα (Tumor Necrosis Factor alpha) and IL-6 (Interleukin 6) will cause severe inflammation even in healthy organs, therefore SLE can affect almost all organs such as joints, skin, brain, eyes, endocrine, lungs, kidneys, and blood vessels.
Early symptoms of this disease are very diverse and often similar to other diseases, so it is quite difficult to detect as early as possible. SLE symptoms can develop suddenly or can last a long time before they relapse.
Symptoms of SLE that often appear are:
• Fever
• Fatigue
• Unusual bleeding
• Hair loss
• Anemia
• Photosensitivity
• Joint pain
• Red rash on cheeks and nose
• Fingers turn pale or blue when cold.
The diagnosis of SLE is made based on the clinical symptoms experienced and investigations. Examination of CRP (C-Reactive Protein), ANA (Anti-Nuclear Antibody), RF Factor (Rheumatoid Factor), and ESR (Erythrocyte Sedimentation Rate) are needed to help diagnose autoimmune disorders.
This laboratory examination to help see the presence of inflammation in the body and autoantibodies that are produced in excess due to impaired immune balance.
The goal of therapy for SLE is to reduce symptoms and protect organs by reducing inflammation or autoimmune activity in the body. Treatment for SLE is based on the severity (mild, moderate, and severe).
Treatments commonly given to SLE patients are:
1. Corticosteroids, such as methylprednisolone, prednisone, dexamethasone.
2. Non-Steroid Anti-Inflammatory Drugs (NSAIDs), such as ibuprofen
3. Immunosuppressants, such as methotrexate and cyclosporine.
4. Biological agents, such as tocilizumab.
5. Antimalarials, such as hydroxychloroquine or chloroquine
Drugs for SLE therapy have various side effects, such as steroids that can cause a moon face (swelling of the face). Giving drugs that suppress the body's immune system makes SLE patients are more susceptible to viral infections, including the COVID-19 virus. Therefore, patients with SLE are required to maintain their health and have regular check-ups with the doctor.
BIOTEK FARMASI INDONESIA has REGIMUN product which is indicated to help maintain body’s immunity. Scientific journals show that the composition of this product has several benefits, namely:
1. Immune regulation, especially NF-kB (Nuclear Factor-kappa beta) and TNF (Tumor Necrosis Factor) which are inflammatory mediators that play a role in the imbalance of the immune system in producing autoantibodies that attack healthy organs.
2. Anti-inflammatory effect
Some of the advantages above provide benefits for users, namely:
1) Helps overcome organ damage due to immune system imbalance
2) Helps overcome inflammation / inflammation
The recommended dose based on ANA (Anti-Nuclear Antibodies) values:
REGIMUN from BIOTEK FARMASI INDONESIA is originator product, not imitating existing ones. This product was developed based on years of research.
Please click the page for more information.
REFERENCES
[1] S. Zhu, R. H. Aspera-Werz, T. Chen, W. Weng, B. Braun, T. Histing and A. K. Nüssler, "Maqui Berry Extract Prevents Cigarette Smoke Induced Oxidative Stress In Human Osteoblasts In Vitro," EXCLI Journal, vol. 20, pp. 281, 291, 2021.
[2] C. L. C´espedes-Acu˜na, J. Xiao, Z.-J. Wei, L. Chend, J. M. Bastias, J. G. Avila, J. Alarcon-Enos, E. Werner-Navarrete and I. Kubog, "Antioxidant And Anti-Inflammatory Effects Of Extracts From Maqui Berry Aristotelia Chilensis In Human Colon Cancer Cells," Journal of Berry Research, vol. 8, p. 275, 2018.
[3] L. S. Wieland, V. Piechotta, T. Feinberg, E. Ludeman, B. Hutton, S. Kanji, D. Seely and C. Garritty, "Elderberry For Prevention And Treatment Of Viral Respiratory Illnesses: A Systematic Review," BMC Complementary Medicine and Therapies, vol. 21, pp. 1-2, 2021.
[4] G. T. T. Ho, HelleWangensteen and H. Barsett, "Elderberry and Elderflower Extracts, Phenolic Compounds, and Metabolites and Their Effect on Complement, RAW264.7 Macrophages and Dendritic Cells," International Journal of Molecular Sciences, vol. 18, pp. 1-2, 2017.
[5] L. Ma, Z. Sun, Y. Zeng, M. Luo and J. Yang, "Molecular Mechanism and Health Role of Functional Ingredients in Blueberry for Chronic Disease in Human Beings," International Journal of Molecular Science, vol. 19, p. 12, 2018.
[6] S. Roth, M. R. Spalinger, I. Müller, S. Lang, G. Rogler and M. Scharl, "Bilberry-Derived Anthocyanins Prevent IFN--Induced Pro-Inflammatory Signalling and Cytokine Secretion In Human THP-1 Monocytic," Digestion, pp. 179-180, 2014.
Other diseases, such as Systemic Lupus Erythematosus (SLE), can affect the entire body. Systemic Lupus Erythematosus (SLE) or commonly known to the public as ‘the disease with a thousand faces’ is a complex autoimmune disease characterized by the formation of autoantibodies that attack healthy cells, tissues and organs, causing severe inflammation, coupled with other clinical symptoms.
The formation of autoantibodies is related to the release of NF-ĸB (Nuclear Factor-Kappa Beta) which is a transcription factor that plays an important role in the regulation of the immune system and inflammatory processes. Activation of NF-ĸB is a normal biological response of the body as a defense from various stimuli that harm the body. The presence of activation of NF-kB will form a balance of the immune system.
Under certain conditions, excessive activation of NF-ĸB will cause an imbalance in the immune system. This imbalance also leads to activation of inflammatory mediators, such as cytokines. Excessive cytokines like TNFα (Tumor Necrosis Factor alpha) and IL-6 (Interleukin 6) will cause severe inflammation even in healthy organs, therefore SLE can affect almost all organs such as joints, skin, brain, eyes, endocrine, lungs, kidneys, and blood vessels.
Early symptoms of this disease are very diverse and often similar to other diseases, so it is quite difficult to detect as early as possible. SLE symptoms can develop suddenly or can last a long time before they relapse.
Symptoms of SLE that often appear are:
• Fever
• Fatigue
• Unusual bleeding
• Hair loss
• Anemia
• Photosensitivity
• Joint pain
• Red rash on cheeks and nose
• Fingers turn pale or blue when cold.
The diagnosis of SLE is made based on the clinical symptoms experienced and investigations. Examination of CRP (C-Reactive Protein), ANA (Anti-Nuclear Antibody), RF Factor (Rheumatoid Factor), and ESR (Erythrocyte Sedimentation Rate) are needed to help diagnose autoimmune disorders.
This laboratory examination to help see the presence of inflammation in the body and autoantibodies that are produced in excess due to impaired immune balance.
The goal of therapy for SLE is to reduce symptoms and protect organs by reducing inflammation or autoimmune activity in the body. Treatment for SLE is based on the severity (mild, moderate, and severe).
Treatments commonly given to SLE patients are:
1. Corticosteroids, such as methylprednisolone, prednisone, dexamethasone.
2. Non-Steroid Anti-Inflammatory Drugs (NSAIDs), such as ibuprofen
3. Immunosuppressants, such as methotrexate and cyclosporine.
4. Biological agents, such as tocilizumab.
5. Antimalarials, such as hydroxychloroquine or chloroquine
Drugs for SLE therapy have various side effects, such as steroids that can cause a moon face (swelling of the face). Giving drugs that suppress the body's immune system makes SLE patients are more susceptible to viral infections, including the COVID-19 virus. Therefore, patients with SLE are required to maintain their health and have regular check-ups with the doctor.
BIOTEK FARMASI INDONESIA has REGIMUN product which is indicated to help maintain body’s immunity. Scientific journals show that the composition of this product has several benefits, namely:
1. Immune regulation, especially NF-kB (Nuclear Factor-kappa beta) and TNF (Tumor Necrosis Factor) which are inflammatory mediators that play a role in the imbalance of the immune system in producing autoantibodies that attack healthy organs.
2. Anti-inflammatory effect
Some of the advantages above provide benefits for users, namely:
1) Helps overcome organ damage due to immune system imbalance
2) Helps overcome inflammation / inflammation
The recommended dose based on ANA (Anti-Nuclear Antibodies) values:
REGIMUN from BIOTEK FARMASI INDONESIA is originator product, not imitating existing ones. This product was developed based on years of research.
Please click the page for more information.
REFERENCES
[1] S. Zhu, R. H. Aspera-Werz, T. Chen, W. Weng, B. Braun, T. Histing and A. K. Nüssler, "Maqui Berry Extract Prevents Cigarette Smoke Induced Oxidative Stress In Human Osteoblasts In Vitro," EXCLI Journal, vol. 20, pp. 281, 291, 2021.
[2] C. L. C´espedes-Acu˜na, J. Xiao, Z.-J. Wei, L. Chend, J. M. Bastias, J. G. Avila, J. Alarcon-Enos, E. Werner-Navarrete and I. Kubog, "Antioxidant And Anti-Inflammatory Effects Of Extracts From Maqui Berry Aristotelia Chilensis In Human Colon Cancer Cells," Journal of Berry Research, vol. 8, p. 275, 2018.
[3] L. S. Wieland, V. Piechotta, T. Feinberg, E. Ludeman, B. Hutton, S. Kanji, D. Seely and C. Garritty, "Elderberry For Prevention And Treatment Of Viral Respiratory Illnesses: A Systematic Review," BMC Complementary Medicine and Therapies, vol. 21, pp. 1-2, 2021.
[4] G. T. T. Ho, HelleWangensteen and H. Barsett, "Elderberry and Elderflower Extracts, Phenolic Compounds, and Metabolites and Their Effect on Complement, RAW264.7 Macrophages and Dendritic Cells," International Journal of Molecular Sciences, vol. 18, pp. 1-2, 2017.
[5] L. Ma, Z. Sun, Y. Zeng, M. Luo and J. Yang, "Molecular Mechanism and Health Role of Functional Ingredients in Blueberry for Chronic Disease in Human Beings," International Journal of Molecular Science, vol. 19, p. 12, 2018.
[6] S. Roth, M. R. Spalinger, I. Müller, S. Lang, G. Rogler and M. Scharl, "Bilberry-Derived Anthocyanins Prevent IFN--Induced Pro-Inflammatory Signalling and Cytokine Secretion In Human THP-1 Monocytic," Digestion, pp. 179-180, 2014.
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